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Last updated: Oct 6, 2025

Clinical study reveals the ingredient that reverts collagen loss and boosts skin elasticity by 29% in just 14 days.

Plus, a perceptible improvement in skin tone (ΔE = 2.53), for a visibly firmer, more even, radiant complexion.

Words by

Celia Robinson

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Published on: Oct 7, 2025

The surprising science behind an upcycled-fruit serum that helps revert collagen loss naturally


It hits you one day in the mirror: your skin doesn’t bounce back like it used to. Fine lines appear. The tone seems uneven and nothing seems to deliver the firmness, brightness, or consistency you once had.

For years, dermatologists believed visible signs of ageing (sagging, dullness, loss of bounce...) could only be addressed at a 'surface-level' improved through prescription-strength actives or in-clinic procedures. True reversal seemed out of reach.

But now, new ingredients and advanced skin-science technology are changing the game. What was once thought impossible, reverting the skin’s firmness, elasticity, and tone from within, is becoming achievable. This promising third-party clinical study on UpCircle’s Peptide Serum is challenging that belief: showing a 29.42% statistically significant improvement in skin elasticity in just 14 days.


And unlike harsh retinols or chemical peels, this lightweight, eco-friendly serum achieves results through a biomimetic Tripeptide Complex that “teaches” the skin to rebuild collagen, without irritation.

We like

Incredible efficacy at a great price point.

Clinically proven results

Derm-approved for sensitive skins

Made in the UK, and 14-day money back guarantee.

B Corp, Plastic-free packaging, and made with upcycled ingredients.

We don't like

Bottle could last longer (lasts around a month and a half)

Short study window

Featured Product

10% Off

Contains the Peptide Serum + Vitamin E Face Moisturiser

Elasticity Boosting Duo
£42
Dryness and elasticity loss? Try this duo! Nourish and boost your skin's elasticity in 14 days! Contains Peptide Serum + Moisturiser.

What makes it different from every other peptide serum?

Here’s the truth brands rarely tell: Most serums stop at hydration. They provide surface-level improvements, but when your skin shifts with age, hormone changes, menopause, barrier fragility, slower repair cycles, those formulas deliver minimal results.


Meanwhile, you don’t just want surface benefits. You want to reverse collagen loss and restore firmness from within. But that takes more than trendy ingredients: it takes a formula optimized for mature skin biology, with carefully balanced actives that deliver without overload.


UpCircle’s formula goes deeper with a collagen-stimulating peptide complex, supported by niacinamide and fruit-derived antioxidants, to improve elasticity and radiance at the same time.


Each drop contains:

  • Biomimetic Tripeptide Complex – Signals collagen production and strengthens the skin’s elastic matrix.

  • Niacinamide (Vitamin B3) – Reinforces the barrier, evens tone, and reduces inflammation.

  • Gentle AHA from citrus fruit – Smooths and brightens dull skin without sting or peeling.

  • Tocopherol (Vitamin E) – Provide antioxidant protection against pollution and UV damage.

  • Blood orange & custard apple extracts – Upcycled botanical waters that add radiance while reducing waste.


Dermatologically approved, vegan, and formulated for sensitive skin. What I love about UpCircle is how they manage to merge performance-led skincare with a waste-fighting, plastic-negative mission.

Inside the clinical results

In a 14-day clinical test with 22 adult volunteers, independent researchers measured two key parameters:

1. Skin Elasticity (Cutometry test)
• Average improvement: +29.42%
• p = 0.0007 (statistically significant)
• Participants served as their own control (before vs. after)

2. Skin Tone Evenness (Colourimetry L*a*b* assessment)
• Overall brightness change (ΔE = 2.53), perceptible at a glance
• Slight reduction in redness (a*) and yellowness (b*)
• Visibly smoother, more even complexion after two weeks


In simple terms: testers’ skin became measurably bouncier and more radiant without irritation or downtime.


Watch the full explanation: Here’s a video from UpCircle co-founder Anna, walking through the details of the test and what the results mean for your skin.


Why collagen loss happens, and how this serum addresses it

From your mid-30s onward, collagen production drops about 1% per year.
Most serums simply coat the surface, but UpCircle’s tripeptide blend mimics the body’s natural repair signals, encouraging fibroblasts to produce fresh collagen and elastin.
The result? Firmer, plumper, smoother skin that feels like it’s “snapped back” to its younger self.

15% Off

THE BEST VALUE

Elasticity Boosting Duo
£47
£42

For best results, UpCircle pairs the clinically tested Peptide Serum with its deeply hydrating Face Moisturiser in the Elasticity Boosting Duo.


The Peptide Serum works first, targeting the root causes of collagen loss with a biomimetic tripeptide complex and niacinamide to restore elasticity, tone, and balance. Lightweight yet potent, it absorbs instantly, leaving skin supple and smooth.


Follow with the Face Moisturiser, a nourishing blend of shea butter, aloe vera, and upcycled argan powder that locks in hydration and supports the serum’s firming benefits. Together, they create a daily ritual that helps skin feel strong, lifted, and luminous.


And because both formulas are dermatologically approved, vegan, and made with upcycled botanicals, you can feel good about what you’re putting on your skin — and what you’re keeping out of the planet’s waste stream.

15% Off

THE HOLY GRAIL PRODUCT

Peptide Serum with Custard Apple + Blood Orange
£0
£25

And now is when you can officially call me obsessed. UpCircle’s Peptide Serum brings together what the beauty industry once treated as opposites: clinical performance and natural integrity.


Backed by a independent studies, it proves that skin can look firmer, brighter, and more resilient, without irritation or compromise. Powered by biomimetic peptides, niacinamide, and upcycled fruit extracts, it supports skin through every stage of life, from early signs of aging to the hormonal shifts of menopause, helping it rediscover its natural strength and radiance.

Many women, including those navigating perimenopause and menopause, have shared their results proudly — posting photos with their Peptide Serum as their “confidence bottle.” These real customers celebrate firmer, brighter, more resilient skin, proving that age and hormonal changes don’t define how radiant you can look.


Parting Thoughts

Eco-friendly meets evidence-based

UpCircle’s signature twist: every ingredient has a second life.
Blood orange water and custard apple extract are repurposed from the juicing industry, keeping usable nutrients out of landfill.
The glass bottle is 100% recyclable, reflecting the brand’s B-Corp and cruelty-free ethos.

You don’t have to choose between sustainability and science. UpCircle proves you can have both.


Real women are noticing the change

“After two weeks, my skin looks firmer and brighter — someone thought I was 40, I’m 62!” – Hannah P.
“Finally, a serum that works and feels good to buy.” – Laura S.

Thousands of reviews echo the same theme: visible firmness, smoother texture, and the quiet confidence of glowing, healthy skin.


Clinically proven. Ethically made. Noticeable in 14 days.

If your mirror shows tired, sagging skin and you’ve tried everything from retinol to collagen powders, this may be the most refreshing discovery of your skincare journey.

👉 Clinical study reveals the ingredient that reverts collagen loss and boosts skin elasticity by 29% in just 14 days →


Check out UpCircle's products and use code CELIA10 for 10% off.

Featured Product

10% Off

Contains the Peptide Serum + Vitamin E Face Moisturiser

Elasticity Boosting Duo

£47
£42
Dryness and elasticity loss? Try this duo! Nourish and boost your skin's elasticity in 14 days! Contains Peptide Serum + Moisturiser.

Shop The Edit

Peptide Serum with Custard Apple + Blood Orange

£0
£25
Clinically proven to improve skin elasticity by 29% in just 14 days and visibly brighten and even skin tone!

Eye Cream with Hyaluronic Acid + Coffee

£0
£22
Made with hyaluronic acid and caffeine to fade dark circles, puffiness and brighten the eye area.

The Caffeinated Duo + Eye Roller Deal

£51
£41
Fade dark circles, puffiness, fine lines, pigmentation and start glowing! Contains Face Oil and Eye Cream.